WebMar 29, 2024 · POMP is overexpressed and participates in the increase of proteasome assembly and activity in psoriatic skin. Title: The proteasome maturation protein POMP … WebAug 3, 2024 · POMP is a chaperone for proteasome assembly and is critical for proteasome incorporation. Interestingly, a recent report published by a US group stated that mutations of PSMG2, encoding for another proteasome chaperone called PAC2, could also cause CANDLE . The clinical manifestations of PRAAS are diverse.
Proteasome Maturation Protein (pomp) Is Associated With …
WebNov 8, 2024 · The POMP gene encodes a chaperone for proper assembly of the proteasome, which is the main cellular nonlysosomal proteolytic machinery that degrades … WebPOMP and proteasome subunits a7 and b5. POMP-silenced organotypic epidermis showed a weak staining of POMP and a weak and patchy staining of a7 proteasome subunits compared to non-transfected and mock-transfected tissue cultures (Fig. 2 A–B), whilst the staining of b5 proteasome subunits was similar between all tissue constructs (Fig. 2 C). calatlantic homes at bridgehaven
Proteasomes in Autoinflammation SpringerLink
WebOct 19, 2007 · There, POMP recruits the remaining β-subunits into the nascent complex and supports the final proteasome maturation . Such a POMP-mediated model allows for … WebMar 29, 2024 · Go to complete Gene record for POMP; Go to Variation Viewer for POMP variants; Summary. The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. WebDegraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum. 3 publications. ... POMP: 80: … cnn swin transformer