Irf4 pathway

Author: lukq

August undefined, 2024

WebIRF4: A gene on chromosome 6p25-p23 that encodes a member of the interferon regulatory transcription factor (IRF) family, which is characterised by an unique tryptophan pentad … WebOverview. Interferon regulatory factor 4 (IRF4) is a gene that encodes a transcription factor protein that functions as a regulator of interferons and interferon-inducible genes. The …

Joe Louis Greenway – Detroit Greenways Coalition

WebMar 21, 2024 · IRF4 (Interferon Regulatory Factor 4) is a Protein Coding gene. Diseases associated with IRF4 include Skin/Hair/Eye Pigmentation, Variation In, 8 and Whipple … WebJP7239597B2 JP2024545734A JP2024545734A JP7239597B2 JP 7239597 B2 JP7239597 B2 JP 7239597B2 JP 2024545734 A JP2024545734 A JP 2024545734A JP 2024545734 A JP2024545734 ... floating freely crossword clue

IRF4 - an overview ScienceDirect Topics

WebMay 25, 2024 · DUSP22-IRF4, fusion in small subset of LyP ( 5%), small and epidermotropic lymphocytes associated with large neoplastic cells in the dermis (CD4- CD8+ or CD4- CD8 … WebJan 22, 2024 · Here, we show that class IA PI3K-mediated signals induce the expression of the transcription factor Pax5, which plays a central role in B cell commitment and differentiation by activating the... WebIRF4. Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, [5] [6] [7] located at 6p25-p23. IRF4 functions as a key regulatory transcription factor in the development of human immune cells. [8] [9] The expression of IRF4 is essential for the differentiation of T lymphocytes and B ... floating frog chlorine

Interferon regulatory factors - Wikipedia

Exosomal circZNF451 restrains anti-PD1 treatment in lung …

IRF4 is an essential regulatory component at various stages of B cell development. In early B cell development, IRF4 functions alongside IRF8 to induce the expression of the Ikaros and Aiolos transcription factors, which decrease expression of the pre-B-cell-receptor. [9] See more Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, located at 6p25-p23. IRF4 functions as a key regulatory transcription factor in the development of … See more IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive … See more IRF4 has been shown to interact with: • Aiolos, • BATF3, • Blimp-1, See more • FactorBook IRF4 • IRF4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article … See more In melanocytic cells the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation: sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. A … See more • Interferon regulatory factors See more • Mamane Y, Sharma S, Grandvaux N, Hernandez E, Hiscott J (January 2002). "IRF-4 activities in HTLV-I-induced T cell leukemogenesis". Journal of Interferon & Cytokine Research. 22 (1): 135–143. doi:10.1089/107999002753452746. PMID 11846984 See more WebJul 1, 2024 · STAT6 is primarily stimulated by IL-4 and IL-13, but other cytokines, such as IL-3, IL-15, interferon (IFN)α, or growth factors, such as platelet-derived growth factor (PDGF), can activate it [1]. The signaling cascade of the STAT6 pathway starts with the engagement of cytokine receptors [3]. floating frog houseWebApr 30, 2009 · IRF4 (also known as pip, MUM1, LSIRF, NFEM5, and ICSAT) is an IRF-family member that is restricted in expression to the immune system, a property it shares with its closely related family member IRF8. IRF4 and IRF8 have evolved as critical mediators of lymphoid-, myeloid-, and dendritic-cell development ( 1 – 5 ). floating frog in magnetic field

"WebJun 21, 2024 · Beyond the finding that the cytokine IL-27 and the transcription factors interferon regulatory factor 4 (IRF4), avian musculoaponeurotic fibrosarcoma (cMAF) and aryl hydrocarbon receptor (AHR)... " - Irf4 pathway

Irf4 pathway

Regulation and role of the transcription factor IRF5 in innate …

WebApr 29, 2014 · IRF4 is composed of a single polypeptide chain containing two independent structural domains, a DNA-binding domain (DBD) and a regulatory domain (RD), which are separated by a flexible linker 11. The N-terminal DBD is highly conserved among IRFs. WebApr 19, 2024 · We have previously demonstrated that this model is dependent on the JMJD3-IRF4 pathway, with GSK-J4 treatment and Irf4 −/− mice being resistant to inflammatory pain (Achuthan et al., 2016). Mice were injected intraplantarly with saline, or combinations of GM-CSF, IFNβ, or DM-αKG, and pain monitored by a change in weight …

Did you know?

WebJan 1, 2015 · IRF4 regulates MYC expression in ALCL. ALCL survival depends on IRF4/MYC signaling. Abstract Anaplastic large cell lymphoma (ALCL) is a distinct entity of T-cell lymphoma that can be divided into 2 subtypes based on the presence of translocations involving the ALK gene (ALK + and ALK − ALCL). WebSep 1, 2006 · IRF4 and IRF8 can function as transcriptional repressors when bound to an ISRE motif but as transcriptional activators when bound to an ETS/ISRE composite DNA …

WebOct 8, 2024 · Silencing of IRF4 also inhibited M2 polarization in macrophages cocultured with H1395-circZNF451 (Fig. 6M). Consistently, macrophage cytokine levels followed similar patterns as the knockdown of ELF4 (Fig. S5F). Collectively, these results suggest that degradation of FXR1 by circZNF451 activates the ELF4–IRF4 pathway in macrophages. WebInterferon regulatory factor 4 (IRF4) has critical roles in immune cell differentiation and function and is indispensable for clonal expansion and effector function in T cells. Here, we demonstrate that the AKT pathway is impaired in murine CD8 + T cells lacking IRF4.

WebApr 12, 2024 · 国家自然基金委通报今年首批八起学术不端案件，七起涉“医”. 4月11日，国家自然科学基金委员会官网通报了2024年查处的不端行为案件第一批次8个案件的处理结果。. 因涉嫌买卖实验数据、伪造实验数据、擅自标注基金项目、未经同意使用他人署名、伪造他人 … WebIRF8 and IRF4 are also involved in the regulation of B and T-cell development at multiple stages. IRF8 and IRF4 function redundantly to drive common lymphoid progenitors (CLPs) …

WebThe significant enrichment of Th17 cell differentiation found in pathway analyses highlight the potential importance of this pathway in JIA etiology. Four candidate genes at genome‐wide significant loci ( SMAD2 , IL1RAP , IL6ST , and …

WebApr 19, 2024 · Here we explore the impact of type I interferon (IFNβ) on macrophage metabolism and its broader impact on cytokine signaling pathways. We find that IFNβ … floating fsmo rolesWebJul 1, 2016 · IRF4 has been identified as an important transcription factor for differentiation of T cells (Th2, Th9 and Th17) or B cells and is required for the function of Treg, thus … floating ft khalid lyricsWebExpression of IRF4 and IRF8 is restricted to the lymphoid and myeloid lineages of the immune system ( 4 ), whereas they are crucial for B lymphocyte development and Th cell differentiation. In addition to a pro-inflammatory role, IRF5 is … greathouse medical transportationWebIRF8 and IRF4 are also involved in the regulation of B and T-cell development at multiple stages. IRF8 and IRF4 function redundantly to drive common lymphoid progenitors (CLPs) to B-cell lineage. IRF8 and IRF4 are also required in the regulation of germinal center (GC) B cell differentiation. Role in Diseases [ edit] greathouse medical transportWebMay 31, 2024 · IRF4 antagonizes IRF5 activation by competing with IRF5 for its interaction with MyD88 ( 33 ). IRF3, which is activated via cytosolic RIG-I-like receptors (RLRs), binds dominantly to the promoter region of the gene encoding the p40 subunit of interleukin 12 ( Il12b) and interferes with the binding of IRF5, which is activated via TLRs ( 49 ). floating frog chlorine dispenserWebAug 14, 2024 · This proposed pro-inflammatory effect of IRF4 in macrophages was also surprising as IRF4 is usually considered to have an anti-inflammatory role in such cells since it down-regulates their production of pro-inflammatory cytokines such as TNF and IL-1β (99–101). Thus, GM-CSF joins the list of cytokines, such as IL-4 and TSLP, which can up ... greathouse midland texasWebDec 3, 2024 · Fig. 7 ADK deficiency inhibits reparative macrophage polarization through the H3K4me3-IRF4 pathway. A, qPCR analysis of the mRNA level of Irf4 in BMDMs from Adk WT and Adk MAC-KO mice … floating full bed plans