Circhif1a

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August undefined, 2024

WebJun 12, 2024 · CircHIF1A may act as a target molecule of breast cancer therapy. Hypoxia is a common phenomenon in solid tumors. The roles of exosomes from hypoxic breast … WebJun 14, 2024 · [Cell Death Discovery] Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated …

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WebJul 15, 2024 · The RNA-binding protein FUS regulates the biogenesis of circHIF1A by interacting with flanking introns, and significantly promotes TNBC growth and metastasis . 4. Cis-Regulatory Elements. In addition to trans-acting factors that regulate circRNA biogenesis, many cis-regulatory elements can also influence the cyclization of RNA. In … WebApr 3, 2024 · This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, … chimneyfree space heater 888

Identification and characteristics of circHIF1A in breast cancer …

WebK The relative RNA levels of circHIF1A and linear HIF1A were analyzed by qRT-PCR assay after treatment with Actinomycin D in MDA-MB-231 cells. L The relative RNA levels of circHIF1A, linear HIF1A ... WebApr 15, 2024 · CircHIF1A promoted TNBC progression both in vitro and in vivo A (left) Cluster heat map showed the differentially expressed genes in MDA-MB-231 cells with circHIF1A overexpression and control cells. WebLoop is the open research network that increases the discoverability and impact of researchers and their work. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. chimney free log set with heater

Sci-Hub CircHIF1A regulated by FUS accelerates triple …

Hypoxia-Induced circRNAs in Human Diseases: From Mechanisms …

WebDec 1, 2024 · The circHIF1A can act as a sponge for miR-580-5p and decrease the level of miR-580-5p, which was shown to target the CD44 molecule (CD44) mRNA and decrease the expression of CD44. In this way, the up-regulated circHIF1A from CAFs-derived exosome in hypoxia can boost the expression of CD44 indirectly, and then enhance the … WebTong Chen et al. (2024) revealed that circHIF1A, which was upregulated in the plasma of BC patients, could be selectively loaded into exosomes secreted by BC cells. CircHIF1A promoted TNBC growth and metastasis by regulating NFIB expression and subcellular location and was involved in the circHIF1A/NFIB/FUS positive feedback loop. graduate school funding optionsWebJan 1, 2024 · In addition to the PI3K/Akt pathways, circRNAs also change tumor glucose metabolism by regulating multiple different signaling pathways. For example, circCUL3 accelerates aerobic glycolysis in gastric cancer by regulating the STAT3/HK2 axis [70].CircHIF1A plays a critical role in the progression of triple-negative breast cancer … graduate school funding

"WebMar 2, 2024 · CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by modulating NFIB expression and translocation 13 March 2024 Tong Chen, Xiaolong Wang, … " - Circhif1a

Circhif1a

WebJan 4, 2024 · Zhan et al. have found that circHIF1A from CAF-derived exosomes can be taken up by breast cancer cells and thus plays an important role in the regulation of cancer stem cell properties by sponging miR-580-5p and therefore changing CD44 expression. In addition, exosomal circsl7a6 secreted by CAFs is reported to promote the initiation of CRC. WebMini-Circuits. Manufacturer Product Number. PHA-1+. Description. IC RF AMP CATV 50MHZ-6GHZ SOT89. Manufacturer Standard Lead Time. 10 Weeks. Detailed …

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WebJun 3, 2024 · Posttranscriptional tRNA modifications are essential for proper gene expression, and defects in the enzymes that perform tRNA modifications ar ... WebJun 14, 2024 · [Cell Death Discovery] Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated fibroblasts exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 …

WebApr 19, 2024 · A recent study revealed that circHIF1A (hsa_circ_0004623) promoted cancer cell proliferation and metastasis in triple-negative breast cancer (TNBC). Mechanistically, circHIF1A regulates the expression and translocation of NFIB through post-transcriptional and post-translational modifications, resulting in activation of the AKT/STAT3 signaling ... WebThe breast cancer cells were used to establish the models in BALB/C nude mice and hypoxia exosomes with circHIF1A shRNA or the controls were injected into the nude …

WebJun 12, 2024 · Europe PMC is an archive of life sciences journal literature. WebRegulation of HIF-1α stability can also be mediated by an oxygen-independent pathway. In the cytoplasm, HIF-1α is bound to heat-shock protein 90 (Hsp90), leading to enhanced …

WebMar 10, 2024 · Epithelial-to-mesenchymal transition (EMT) is a dynamic program of cell plasticity aberrantly reactivated in cancer. The crosstalk between tumor cells and the tumoral microenvironment (TME) has a pivotal importance for the induction of the EMT and the progression toward a malignant phenotype. Notably, exosomes are key mediators of this …

WebAug 1, 2024 · In addition, circHIF1A (circ_0032138) was upregulated in the exosomes, derived from hypoxic Carcinoma-Associated Fibroblasts (CAFs) with time-dependent manner, however it was not influenced by HIF ... chimney free stove heaterWebAug 20, 2024 · The RNA-binding protein FUS regulates the biogenesis of circHIF1A by interacting with flanking introns, and significantly promotes TNBC growth and metastasis . Go to: 4. Cis-Regulatory Elements. In addition to trans-acting factors that regulate circRNA biogenesis, many cis-regulatory elements can also influence the cyclization of RNA. In ... graduate school funnyWebJan 11, 2024 · In support of circHIF1A as a biomarker and target molecule for breast cancer therapy, Zhan and colleagues identified this molecule in a screening of circRNA present in exosomes from hypoxic CAFs in breast cancer . circHIF1A from hypoxic CAFs-derived exosomes proved to be an important player in conferring stem cell properties to breast … chimney free midway electric fireplaceWebIn BC, sEVs derived from hypoxic CAFs show higher circHIF1A levels than normoxic CAFs. circHIF1A acts as a sponge for miR-580-5p, lowering its levels, whilst miR-580-5p targets the CD44 molecule mRNA, decreasing CD44 expression . Protein transfer from CAFs to cancer cells through sEVs also plays an essential role in tumorigenesis. Breast ... chimney free wall mount electric fireplaceWebMoreover, circHIF1A could be packaged into exosomes and was upregulated in the plasma of breast cancer patients. Our findings indicated that circHIF1A played a critical role in the growth and metastasis of TNBC via a positive feedback loop and that circHIF1A could be a promising biomarker for breast cancer diagnosis and a potential therapeutic ... chimney free infrared quartz heaterWebcircHIF1A-miRNA-149-5p Interaction with NFIB: Promotion of cell proliferation and metastasis: 0.897: Chen 2024 : Table 2. Summary of the prognostic and predictive role of blood circulating ncRNAs for TNBC (AUC—area under the ROC, CR—complete response, HR—hazard ratio, OR—odds ratio, OS—overall survival, PD—progressive disease, PR ... chimney french graduate school goal statement format